As the pharmaceutical industry faces increasing pressure to bring new and better drugs to market earlier, formulation scientists are challenged to reduce expensive, time-consuming animal and human trials. Accurate predictions of oral absorption based on physicochemical properties can help identify and mitigate formulation risk factors prior to FIA trials. This webinar presents a case study of mechanistic oral absorption simulation for the drug ziprasidone , a hydrochloride salt demonstrating a number of challenges for effective formulation. The presentation is based on work done in gCOAS, a new analysis tool for a priori prediction of drug absorption.