Prediction of drug absorption in the human intestine - a case study

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As the pharmaceutical industry faces increasing pressure to bring new and better drugs to market earlier, formulation scientists are challenged to reduce expensive, time-consuming animal and human trials. Accurate predictions of oral absorption based on physicochemical properties can help identify and mitigate formulation risk factors prior to FIA trials. This webinar presents a case study of mechanistic oral absorption simulation for the drug ziprasidone , a hydrochloride salt demonstrating a number of challenges for effective formulation. The presentation is based on work done in gCOAS, a new analysis tool for a priori prediction of drug absorption.

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