ADDoPT Digital Design Showcase

The ADDoPT project partners invite you to join us for our final showcase event, presenting and demonstrating the range of industry-ready new models, tools and approaches for digital design and operation of drug manufacturing processes and product performance arising from this major UK supply-chain collaboration involving AZ, BMS, GSK, Pfizer and various technology and research partners.

Aligned with and preceding the Made Smarter report, the ADDoPT partners have over the last four years been working across the pharmaceutical value chain to define and populate an Industry 4.0 framework for top-down, knowledge-driven digital design of drug products as well as digital design and operation of their manufacturing processes (smart manufacturing), and to identify and develop appropriate modelling approaches to support this.

Bringing together a wide range of mechanistic, statistical and hybrid predictive models and insight from industrial case studies applying them at four major pharmaceutical companies, this FREE event will exemplify business benefits including:

  • better and much earlier understanding of development risks
  • better decision making and resource prioritisation
  • more targeted and efficient experimentation
  • accelerated product development
  • better design and scale-up for robust products and processes.

Co-located with, and on the day following, the 2019 Advanced Process Modelling Forum, the ADDoPT Digital Design Showcase presents a unique opportunity to hear about and see

  • working demonstrations of new tools bringing together best in class predictive science and data analytic approaches to create digital twins of manufacturing processes and products
  • how these are being used in systems-based approaches linking molecular and material properties with process and product performance
  • the transformational opportunities of Industrial Digitalisation for the pharmaceutical value chain (including CROs and CMOs) and for anyone involved in the formulation-based process industries.


10:00 Registration
10:15 Welcome & context
Andy Jones, Medrus Pharma
10:30 ADDoPT overview: Motivation, Scope & Systems-based Approach
Costas Pantelides, PSE
10:50 Overview of industrial case studies
Richard Storey, AZ; Martyn Ticehurst, Pfizer
Digital Design - Molecular-Material level
11:00 From a large dataset of crystal structures to understanding of the chemical space of pharmaceuticals
CCDC; STFC Hartree; University of Leeds
11:20 Lattice energy predictions
Colin Edge, GSK; Klimentina Pencheva, Pfizer
Digital Design - Particle-Product level
11:40 A DEM approach to prediction of flowability
James Elliott, University of Cambridge
12:00 Flowability of APIs in context of continuous drug product manufacture
Mike Tobyn, BMS; tbd, AZ; tbd, GSK; tbd, Pfizer; tbd, Hartree
12:20 Lunch, Posters & Demo Stations
Digital Design - Product-Process level
13:20 To be confirmed
Kevin Roberts, University of Leeds
13:40 Mechanistic Model-based Digital Design framework for individual and integrated manufacturing steps
Sean Bermingham, PSE; Alastair Florence, Strathclyde
14:00 Solid Drug Product and Process Design using Multi-Scale Interconnected Flowsheet Modelling and Global System Analysis
Marta Moreno-Benito, Pfizer
14:20 Visualising Digital Design Workflows
Rob Peeling, Britest; Charlie Gordon, Britest
14:40 Tea Break, Posters & Demo Stations
From Digital Design to Digital Operation
15:25 Taking mechanistic models from R&D and Engineering into Operations
Andy Mitchell, PEL; Niall Mitchell, PSE
15:45 To be confirmed
Flavien Susanne, GSK
16:05 Application of hybrid models for Advanced Process Control of a Twin Screw Wet Granulation Process
Gavin Reynolds, AZ
16:25 ADDoPT Legacy & further developments
Bob Docherty, Pfizer
16:45 Reception - discussions on "What next?"
17:15 Close

Register now

ADDoPT is a collaboration instigated by the Medicines Manufacturing Industry Partnership, and part funded under the Advanced Manufacturing Supply Chain Initiative, a BEIS initiative delivered by Finance Birmingham and Birmingham City Council.

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