ADDoPT Digital Design Showcase
The ADDoPT project partners invite you to join us for our final showcase event, presenting and demonstrating the range of industry-ready new models, tools and approaches for digital design and operation of drug manufacturing processes and product performance arising from this major UK supply-chain collaboration involving AZ, BMS, GSK, Pfizer and various technology and research partners.
Aligned with and preceding the Made Smarter report, the ADDoPT partners have over the last four years been working across the pharmaceutical value chain to define and populate an Industry 4.0 framework for top-down, knowledge-driven digital design of drug products as well as digital design and operation of their manufacturing processes (smart manufacturing), and to identify and develop appropriate modelling approaches to support this.
Bringing together a wide range of mechanistic, statistical and hybrid predictive models and insight from industrial case studies applying them at four major pharmaceutical companies, this FREE event will exemplify business benefits including:
- better and much earlier understanding of development risks
- better decision making and resource prioritisation
- more targeted and efficient experimentation
- accelerated product development
- better design and scale-up for robust products and processes.
Co-located with, and on the day following, the 2019 Advanced Process Modelling Forum, the ADDoPT Digital Design Showcase presents a unique opportunity to hear about and see
- working demonstrations of new tools bringing together best in class predictive science and data analytic approaches to create digital twins of manufacturing processes and products
- how these are being used in systems-based approaches linking molecular and material properties with process and product performance
- the transformational opportunities of Industrial Digitalization for the pharmaceutical value chain (including CROs and CMOs) and for anyone involved in the formulation-based process industries.
Agenda
09:30 | Registration & refreshments |
10:10 | Welcome Sean Bermingham, PSE |
10:15 | ADDoPT, a View from Several Perspectives Andy Jones, Innovate UK (UKRI) |
10:30 | ADDoPT overview: Motivation, Scope & Systems-based Approach Sean Bermingham, PSE |
10:50 | Overview of industrial case studies Richard Storey, AZ; Martyn Ticehurst, Pfizer |
Digital Design - Molecular-Material level | |
11:00 | From a large dataset of crystal structures to understanding of the chemical space of pharmaceuticals Andy Maloney, CCDC; Rebecca Mackenzie, STFC Hartree; Kevin Roberts, University of Leeds; Helen Blade, AZ; Bob Docherty, Pfizer |
11:20 | Lattice energy predictions Rebecca Mackenzie, STFC; Colin Edge, GSK; Klimentina Pencheva, Pfizer |
Digital Design - Particle-Product level | |
11:40 | A DEM approach to prediction of flowability James Elliott, University of Cambridge |
12:00 | Flowability of APIs in context of continuous drug product manufacture Mike Tobyn, BMS; Richard Storey, AZ; Kendal Pitt, GSK; Martyn Ticehurst, Pfizer; Stephen Checkley, Hartree |
12:20 | Lunch, Posters & Demo Stations |
Digital Design - Product-Process level | |
13:20 | First principles modelling for particle and process design Kevin Roberts, University of Leeds |
13:40 | Mechanistic Model-based Digital Design framework for individual and integrated manufacturing steps David Slade, PSE; Alastair Florence, Strathclyde |
14:00 | Solid Drug Product and Process Design using Multi-Scale Interconnected Flowsheet Modelling and Global System Analysis Marta Moreno-Benito, Pfizer |
14:20 | Visualising Digital Design Workflows Rob Peeling, Britest; Charlie Gordon, Britest |
14:40 | Tea Break, Posters & Demo Stations |
From Digital Design to Digital Operation | |
15:25 | Taking mechanistic models from R&D and Engineering into Operations Andy Mitchell, PEL; Niall Mitchell, PSE |
15:45 | How process simulation can influence the control strategy of a Drug Substance asset Flavien Susanne, GSK |
16:05 | Application of hybrid models for Advanced Process Control of a Twin Screw Wet Granulation Process Gavin Reynolds, AZ |
16:25 | Panel discussion "Future of Digitalization in the Formulated Product Industries" Bob Docherty, Pfizer; Jim Litster, University of Sheffield; Ben Weinstein, P&G; Lynne McGregor, Innovate UK (UKRI); Anita Rea, SyngentaDiego Larrain, Nestlé |
16:45 | Reception - discussions on "What next?" |
17:30 | Close |
ADDoPT is a collaboration instigated by the Medicines Manufacturing Industry Partnership, and part funded under the Advanced Manufacturing Supply Chain Initiative, a BEIS initiative delivered by Finance Birmingham and Birmingham City Council.
More Information
Date & Time
28 March 2019
09:30–17:30
Cost
Free
Location
Clayton Hotel Chiswick
626 Chiswick High Road
London W4 5RY
Hotel reservations
Clayton Hotel Chiswick
The rate is £136 for Sunday and Thursday nights
And £166 for Monday to Wednesday inclusive.
Both rates are inclusive of VAT and breakfast and this will expire on 12th March.
To book a room at the Clayton: Quote the code PROC250319 via email to [email protected] or via phone +44 208 996 5200, Option 1.
For any questions, please feel free to contact our event manager Lylia Djebaili at [email protected]