ADDoPT Digital Design Showcase

The ADDoPT project partners invite you to join us for our final showcase event, presenting and demonstrating the range of industry-ready new models, tools and approaches for digital design and operation of drug manufacturing processes and product performance arising from this major UK supply-chain collaboration involving AZ, BMS, GSK, Pfizer and various technology and research partners.

Aligned with and preceding the Made Smarter report, the ADDoPT partners have over the last four years been working across the pharmaceutical value chain to define and populate an Industry 4.0 framework for top-down, knowledge-driven digital design of drug products as well as digital design and operation of their manufacturing processes (smart manufacturing), and to identify and develop appropriate modelling approaches to support this.

Bringing together a wide range of mechanistic, statistical and hybrid predictive models and insight from industrial case studies applying them at four major pharmaceutical companies, this FREE event will exemplify business benefits including:

  • better and much earlier understanding of development risks
  • better decision making and resource prioritisation
  • more targeted and efficient experimentation
  • accelerated product development
  • better design and scale-up for robust products and processes.

Co-located with, and on the day following, the 2019 Advanced Process Modelling Forum, the ADDoPT Digital Design Showcase presents a unique opportunity to hear about and see

  • working demonstrations of new tools bringing together best in class predictive science and data analytic approaches to create digital twins of manufacturing processes and products
  • how these are being used in systems-based approaches linking molecular and material properties with process and product performance
  • the transformational opportunities of Industrial Digitalization for the pharmaceutical value chain (including CROs and CMOs) and for anyone involved in the formulation-based process industries.


09:30 Registration & refreshments
10:10 Welcome
Sean Bermingham, PSE
10:15 ADDoPT, a View from Several Perspectives
Andy Jones, Innovate UK (UKRI)
10:30 ADDoPT overview: Motivation, Scope & Systems-based Approach
Sean Bermingham, PSE
10:50 Overview of industrial case studies
Richard Storey, AZ; Martyn Ticehurst, Pfizer
Digital Design - Molecular-Material level
11:00 From a large dataset of crystal structures to understanding of the chemical space of pharmaceuticals
Andy Maloney, CCDC; Rebecca Mackenzie, STFC Hartree; Kevin Roberts, University of Leeds; Helen Blade, AZ; Bob Docherty, Pfizer
11:20 Lattice energy predictions
Rebecca Mackenzie, STFC; Colin Edge, GSK; Klimentina Pencheva, Pfizer
Digital Design - Particle-Product level
11:40 A DEM approach to prediction of flowability
James Elliott, University of Cambridge
12:00 Flowability of APIs in context of continuous drug product manufacture
Mike Tobyn, BMS; Richard Storey, AZ; Kendal Pitt, GSK; Martyn Ticehurst, Pfizer; Stephen Checkley, Hartree
12:20 Lunch, Posters & Demo Stations
Digital Design - Product-Process level
13:20 First principles modelling for particle and process design
Kevin Roberts, University of Leeds
13:40 Mechanistic Model-based Digital Design framework for individual and integrated manufacturing steps
David Slade, PSE; Alastair Florence, Strathclyde
14:00 Solid Drug Product and Process Design using Multi-Scale Interconnected Flowsheet Modelling and Global System Analysis
Marta Moreno-Benito, Pfizer
14:20 Visualising Digital Design Workflows
Rob Peeling, Britest; Charlie Gordon, Britest
14:40 Tea Break, Posters & Demo Stations
From Digital Design to Digital Operation
15:25 Taking mechanistic models from R&D and Engineering into Operations
Andy Mitchell, PEL; Niall Mitchell, PSE
15:45 How process simulation can influence the control strategy of a Drug Substance asset
Flavien Susanne, GSK
16:05 Application of hybrid models for Advanced Process Control of a Twin Screw Wet Granulation Process
Gavin Reynolds, AZ
16:25 Panel discussion "Future of Digitalization in the Formulated Product Industries"
Bob Docherty, Pfizer; Jim Litster, University of Sheffield; Ben Weinstein, P&G; Lynne McGregor, Innovate UK (UKRI); Anita Rea, SyngentaDiego Larrain, Nestlé
16:45 Reception - discussions on "What next?"
17:30 Close

Register now

ADDoPT is a collaboration instigated by the Medicines Manufacturing Industry Partnership, and part funded under the Advanced Manufacturing Supply Chain Initiative, a BEIS initiative delivered by Finance Birmingham and Birmingham City Council.

More Information

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Date & Time
28 March 2019



Clayton Hotel Chiswick
626 Chiswick High Road
London W4 5RY

Hotel reservations

Clayton Hotel Chiswick

The rate is £136 for Sunday and Thursday nights
And £166 for Monday to Wednesday inclusive.
Both rates are inclusive of VAT and breakfast and this will expire on 12th March.

To book a room at the Clayton: Quote the code PROC250319 via email to [email protected] or via phone +44 208 996 5200, Option 1.

For any questions, please feel free to contact our event manager Lylia Djebaili at [email protected]