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New technology has potential to transform pharma manufacture
Pfizer outlines Systems-based Pharmaceutics vision to enhance drug performance at the Advanced Process Modelling Forum in London
We are very excited to share leading pharmaceuticals company Pfizer's vision for Systems-based PharmaceuticsTM, a revolutionary model-based approach linking drug process and product engineering to product quality and performance in the human body. Pfizer's vision was presented at the recent Advanced Process ModellingTM Forum in London.
Keynote speaker Ravi Shanker, Senior Research Fellow at Pfizer, said it is essential that pharmaceutical companies develop better methodologies to ensure the quality and efficacy of their products. This can only be achieved reliably and efficiently by developing a quantitative understanding of how decisions relating to the way the drug is manufactured affect the drug's behaviour within the body. He added, "Adopting a system-wide modelling approach is essential in this context".
The Advanced Process Modelling Forum, aimed at senior business and technology decision makers in pharmaceuticals, oil & gas, power generation, chemicals, petrochemicals, food, minerals & mining and other process industry sectors, focused real-world opportunities to create sustainable value through the application of high-accuracy predictive process modelling.
Other presenters in the dedicated Life Sciences session included Eli Lilly, GSK, SABIC, SASOL, Sulzer Chemtech and research organisations TNO, the Rutgers University ERC-SOPS consortium and Imperial College London. Focus was the application of model-based techniques to enhance manufacturing process design and scale-up, optimise operations, accelerate process innovation and manage new technology risk, with a focus on laboratory-to-industrial-process workflows for reducing time-to-market for new developments.
Pharma companies are adopting advanced process modelling technology to rapidly accelerate value creation as part of Quality-by-Design (QbD) approaches, in particular by facilitating the move from batch to continuous processing and optimising solids process design and operation.
Organiser Mark Matzopoulos, PSE's COO, says "advanced process modelling is about using predictive models to explore the design space rapidly, reduce uncertainty and make better, faster and safer decisions. The range and diversity of presentations at the forum illustrates the power that the technology has to transform the way the process industries design and operate."
[Press release] [PDF] [More about the APM Forum]
gSOLIDS 2.0 released
Second generation advanced process modelling for solids process design and operation
We are pleased to announce the release of gSOLIDS 2.0, PSE's second-generation integrated drag & drop graphical flowsheeting environment for model-based engineering and optimisation of solids processes.
Developed in conjunction with Procter & Gamble, Pfizer and Novozymes, gSOLIDS is aimed at process engineers and scientists in industries where particulate processes play an integral part, such as pharmaceuticals, fine chemicals, agrochemicals, food processing, consumer goods and minerals and mining.
Ben Weinstein, section head of Corporate Function R&D Modeling & Simulation at Procter & Gamble, says: "a key advantage of gSOLIDS is that it allows our modellers to develop dynamic models of complex processes and apply them to analyse process dynamics." The ability to exploit optimisation-based capabilities such as parameter estimation and dynamic optimisation using accurate models means that it is possible, for example, to determine optimal operating procedures. "This ultimately gives us a better likelihood that when we start up a new product line it will work as planned" says Weinstein.
Sean Bermingham, VP of PSE's Solids strategic business, says "This second-generation tool establishes PSE firmly at the forefront of advanced process modelling for solids processing, an area where significant scientific and economic benefits can be achieved by combining modelling and experimental approaches."
New in gSOLIDS 2.0 is the ability to handle multiple solid phases, each with its own particle size distribution and size dependent composition, plus numerous new unit operation models. In addition there are enhancements to a number of gSOLIDS' unique capabilities, such as the use of dynamic modelling to handle batch, continuous and hybrid processes; advanced parameter estimation and optimisation capabilities; and integration with PSE's leading gCRYSTAL advanced process modelling software and gas-liquid process models to enable simultaneous whole-process design and optimisation.
Bermingham says "Our Advisory Board and close collaboration with leading research consortia such as C-SOPS enable us to incorporate the latest developments rapidly and facilitate knowledge transfer between academia and industry. The advances in usability brought by gSOLIDS 2.0 now make these game-changing benefits accessible to a growing community of engineers and scientists."
[Press release] [PDF] [more on gSOLIDS]
PSE Inc. welcomes Purdue to The Partnership for Advanced Process Modeling
Advanced industrial software available to chemical engineering students
We are pleased to announce the signing of Purdue University as the latest US university to join our Partnership for Advanced Process Modelling.
PSE will contribute its leading gPROMS® platform software, model libraries and training services to the partnership with Purdue University's Chemical Engineering Department. The university will drive adoption of advanced process modeling technology to its graduate and undergraduate chemical engineering students, teaching staff and selected industrial participants.
"The Partnership for Advanced Process Modeling continues to gain momentum," said Dale Curtis, President of PSE Inc. "It demonstrates the demand for universities to have access to the same powerful tools as used within industry to create and capture sustainable value. Our goal is for engineering students to understand how to apply the unique opportunities available with advanced processing modeling tools, so that they too can become part of a powerful ecosystem that is making a big difference in innovation, safety and effectiveness."
Purdue University is excited to be a key US partner in this vital initiative", said Jim Litster, Professor of Chemical Engineering and Professor of Industrial and Physical Pharmacy. "As a member of PSE's gSOLIDS Advisory Board and an organization that has already adopted PSE's solids process modeling software, we understand the need to provide our students with the most advanced tools industry needs to win in a competitive global economy. The tools and expertise made available in this Partnership for Advanced Process Modeling enable us to remain competitive while achieving breakthrough results in our programs."
Advanced Process Modelling forum summary 1
Shell, SASOL, Süd-Chemie place process modelling at heart of economic decisions
This week's Advanced Process Modelling Forum in London saw leading process industry players describe how high-fidelity process modelling is increasingly at the heart of major economic decisions.
Keynote speaker Jan van Schijndel, Manager of XTL Development at Shell, described how process modelling is a key component in determining economically optimal synthesis of large-scale gas-to-liquid (GTL) plants such as the $18bn Pearl development in Qatar. Cayle Sharrock of South African GTL company SASOL described how high-fidelity models of the core Fischer-Tropsch reactor are used in plant-wide optimisations to substantially increase ROI for future designs.
Catalytic technologies provider Süd-Chemie described how advanced process modelling using detailed catalyst and reactor models allows the company not only to accelerate catalyst development but also to provide services to optimise customers' operations, for example by maximising reactor catalyst life.
The forum is an annual event organised by Process Systems Enterprise (PSE), a leading supplier of Advanced Process Modelling technology and services. Attended by senior business and technology decision makers in pharmaceuticals, oil & gas, power generation, chemicals, petrochemicals, food, minerals & mining and other process industry sectors, it focuses on the creation of sustainable value through the application of high-accuracy predictive process modelling.
Andrew Green of the Energy Technologies Institute (ETI) explained the key role of system-wide modelling tools to help accelerate and de-risk carbon capture & storage (CCS) developments in the UK. The ETI has invested in a £3m project in which PSE and industry partners E.ON, EDF, Rolls-Royce and Petrofac are creating gCCS, a modelling environment for techno-economic decision support based on PSE's gPROMS advanced process modelling platform.
Other presenters included Pfizer, Eli Lilly, GSK, SABIC, Sulzer Chemtech and research organisations TNO, the Rutgers University ERC-SOPS consortium and Imperial College London. Presentations described the application of model-based techniques to enhance manufacturing process design and scale-up, optimise operations, accelerate process innovation and manage new technology risk, including laboratory-to-industrial-process workflows for reducing time-to-market for new developments.
PSE announced the release of gSOLIDS 2.0, second-generation solids process modelling software, and v2.0 of its gCRYSTAL software for design, scale-up and optimisation of crystallisation processes. The company also provided a preview of v4.0 of its gPROMS advanced process modelling platform to be released later this year.
Organiser Mark Matzopoulos, PSE's COO, says "advanced process modelling is about using predictive models to explore the design space rapidly, reduce uncertainty and make better, faster and safer decisions. The range and diversity of presentations at the forum illustrates the power of the technology to transform the way the process industries design and operate."
Process Systems Enterprise Inc. announces the formation of The Partnership for Advanced Process Modeling
Carnegie Mellon signs on as first university partner in the US
Cedar Knolls, NJ, April 3, 2012 --- Process Systems Enterprise Inc. (PSE), the Advanced Process ModelingTM company, today announced the creation of The Partnership for Advanced Process Modeling, a global initiative to accelerate the use of advanced process modeling at leading engineering universities. PSE also announced the signing of Carnegie Mellon University as the first US University partner.
PSE, a spin-out of Imperial College London, England, will contribute to the Partnership with Carnegie Mellon's Center of Advanced Process Decision-making its leading gPROMS® platform software, model libraries, and training services. The universities will drive exposure and adoption of the technology of advanced process modeling to its chemical engineering students at the graduate and undergraduate level, the teaching staff, and selected industrial participants.
gPROMS, the world's leading advanced process modeling platform, is used by process companies around the world to make better, faster and safer design and operating decisions by reducing uncertainty. This enables reduced time-to-market for new processes or products, better-managed development risk, improved designs, enhanced production, reduced capital and operating expenditure and better compliance with safety, health and environmental requirements.
The package is applied in all sectors of the process industries, in particular those with complex operations such as reaction, separation, crystallization, polymerization and fuel cell processes.
"The Partnership for Advanced Process Modeling is a critical initiative at a crucial time”, said Dale Curtis, President of Process Systems Enterprise, Inc. "As more process-centric companies look for ways to create and capture sustainable value, the power of advanced process modeling needs to become more integral to those efforts. Our goal is for engineering students to see what we see – that advanced process modeling is a value magnet, capable of driving revenue growth, costs savings and risk mitigation.”
"Carnegie Mellon University is pleased to be the inaugural US partner in this vital initiative”, said Professor Ignacio Grossmann, Director of CMU's Center for Advanced Process Decision-making (CAPD). "We understand we need to provide the next generation of industry practitioners with the most advanced tools industry needs to win in a competitive global economy. Along with our research at CAPD, this Partnership with PSE enables us to do just that.”
Contact: James Wade, Marketing Manager
Tel 973 290 9559, e:j.wade@psenterprise.com
Editors' materials: http://www.psenterprise.com/pr120403.html
About Carnegie Mellon University and the CAPD
Carnegie Mellon (www.cmu.edu) is a private, internationally ranked research university located in Pittsburgh with programs in areas ranging from science, engineering and business, to public policy, the humanities and the arts With more than 11,000 students in the university's seven schools and colleges, its education and research is characterized by its focus on creating and implementing solutions for real problems, interdisciplinary collaboration and innovation.
Carnegie Mellon is an international leader in the area of process systems engineering. Its Center for Advanced Process Decision-making (capd.cheme.cmu.edu) is in the forefront of process modelling and optimization for the process industries. The research in the CAPD is led by Professors Biegler, Grossmann, Sahinidis, Siirola, and Ydstie in the areas of modelling and optimization algorithms, process synthesis and product design, energy systems, enterprise-wide optimization, process operations, and molecular computing.
The CAPD has over 20 international industrial affiliates in the petroleum, chemicals, consumer products, pharmaceuticals, engineering and software sectors. The research is performed by over 40 postgraduate and postdoctoral students with funding from the National Science Foundation, Department of Energy and member companies. Many of its graduates have become leading researchers in universities and in industry.
The inaugural 2012 Advanced Process Modelling Forum
Shell, Pfizer keynotes on Gas-to-Liquid conversion, Systems-based Pharmaceutics
LONDON, 28 March 2012 --- Process Systems Enterprise (PSE), providers of the world-leading gPROMS® advanced process modelling platform and related ModelCare® services, will host the inaugural 2012 Advanced Process Modelling Forum in London on 18 and 19 April.
The forum is a key event for process industry companies focused on creating sustainable value through the application of high-accuracy predictive modelling. It is aimed at senior business and technology decision makers in process industries such as pharmaceuticals, oil & gas, power generation, chemicals, petrochemicals, food and minerals & mining.
Organiser Mark Matzopoulos, PSE's COO, says "advanced process modelling is about using predictive models to explore the design space rapidly, reduce uncertainty and make better, faster and safer decisions. Traditionally this has been the preserve of the large-scale process industries, but we have a very strong Life Sciences element at the Forum, with Pfizer, GSK and Eli Lilly presenting. Expect some exciting announcements in this area."Pharma companies are adopting the technology rapidly to accelerate value creation, in particular by facilitating the move from batch to continuous processing and optimising solids process design and operation.
The two keynote speakers will be Jan van Schijndel, Manager of XTL Development at Shell, and Ravi Shanker, Senior Research Fellow at Pfizer. Van Schijndel will describe how Shell is developing model-based synthesis tools to support development of the next generation of Gas-to-Liquid (GTL) plants, based on experience from the huge Pearl development in Qatar. Shanker's focus will be Systems-based Pharmaceutics, a revolutionary model-based approach for optimising drug manufacturing by taking a holistic view that encompasses both biological effects in the human body and drug process and product engineering.
GSK, Eli Lilly, SABIC, SASOL, Süd-Chemie and Sulzer Chemtech will also be presenting, as will research organisations TNO, Rutgers University and Imperial College London, and the Energy Technologies Institute (ETI). Presentations will cover the application of model-based techniques to enhance process design and scale-up, optimise operations, accelerate process innovation and manage new technology risk, with a focus on laboratory-to-industrial-plant workflows for large-scale new process development.
Other highlights include presentations on the ETI's investment in a system-wide modelling tool-kit to accelerate and de-risk the development of carbon capture & storage (CCS) in the UK, and on recent developments in SAFT advanced thermodynamics techniques that makes it possible to achieve unprecedented accuracy in thermodynamic predictions with little or no data.
Prof. Costas Pantelides, MD of PSE says "The diversity and scale of applications that generate real value show that advanced process modelling is becoming a key technology for process industry innovators. We believe that this will drive a step change in value creation across all process sectors, which should capture the attention not only of practitioners but also operating executives with P&L responsibility.”
PSE announces release of gCRYSTAL
Integrated model-based engineering and optimisation of crystallisation processes
LONDON, 15 September 2011 --- Process Systems Enterprise (PSE), providers of the world-leading gPROMS® high-fidelity process modelling environment and related ModelCare®services, today announced the release of its new gCRYSTAL® product.
gCRYSTAL provides an integrated, easy-to-use, drag and drop graphical environment for model-based innovation, engineering and optimisation of solution crystallisation processes. The package is aimed at scientists and process engineers in industries where crystallisation processes - including precipitation - play an integral part, such as pharmaceuticals, food, chemicals and mineral processing, and has been developed with several years of input from leading companies in these sectors.
Uniquely combining ease of use with modelling power, gCRYSTAL provides detailed population balance-based models containing first-principles representations of the complex crystallisation physics and chemistry, as well as facilities for validating models against multiple sets of data from steady-state and dynamic experiments. The resulting high-fidelity predictive models are used to optimise crystallisation process design and operation, determine the optimal process economics subject to product quality constraints and quantify and manage the risks associated with engineering decisions, for both batch and continuous processes.
Dr Sean Bermingham, VP for Strategic Business Development in PSE's Solids modelling business, says "despite the importance of crystallisation processes to industry and society, there has been a notable lack of effective modelling tools in this area until now. We believe that gCRYSTAL brings a step change to the capabilities available to industry".
Crystallisation processes are notoriously difficult to scale up, and there is often little understanding of the fundamental phenomena occurring, meaning that there is often large scope for process optimisation. Bermingham says, "New model-based techniques now make scale-up from laboratory bench to industrial size much easier and more reliable. In addition, proper quantification makes it possible to achieve higher throughput and better and consistent quality, often with large energy savings". As an example, Friesland Campina reported a 44% reduction in batch time after optimising a cooling crystallisation process for production of pharmaceutical-grade lactose.
gCRYSTAL links with PSE's gSOLIDS® product to support design and optimisation of integrated vapour-liquid-solid processes, including the full downstream solids handling.
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