Biotechnology process modelling

New power to optimise complex process design and operation

Advanced Process Modelling for food & beverages

The benefits of modelling

Advanced Process Modelling provides definitive answers to complex biotreatment questions:

What is the complete atomic accountability for up to fifty degradable substrates?
What is the exact nutrient usage, CO2 generation, inorganic solid formation and VOC release?
What is the optimum pH control scheme to minimise reagent usage and promote microbial growth?
How will the process respond to startup, shutdown and shock loads?
What is the optimal number of bioreactors, reactor size and oxygen injection points?

Similar considerations apply to fermentation.

By answering questions such as these with high-quality quantitative information, you can:

gain deep understanding of the process, leading to better design and operational decisions
design better processes, leading to improved product quantity and quality
determine the optimal number of stages for the required loads, saving unnecessary capital expenditure
determine optimal startup sequences and operational procedures, leading to more reliable operation
monitor operations and optimise production trajectories, leading to shorter batch time and lower risk of failed batches.

See our white paper for more information on how APM is applied to biotreatment processes.

PSE's solutions can be applied to bring a new level of rigour and accuracy to modelling of biotechnology processes.

gPROMS provides the ability to model bioprocesses such as biotreatment and fermentation to virtually any degree of complexity, for feasibility studies, debottlenecking or capacity increases, investigation of various "what-if" scenarios, control studies or rigorous design applications.

Users can choose to write their own models or to use PSE's advanced biotechnology models as a starting point.

Either way, unlike traditional biotechnology modelling software, they have full access to the basic mathematical models describing the chemistry, thermodynamics, kinetics, mass transfer and all other defining equations.

What PSE offers

PSE brings a powerful combination of state-of-the-art tools and expert services to designers or operators of biotechnology processes:

gPROMS Advanced Process Modelling environment, which has many powerful features previously unavailable to modellers of biotechnology processes
PSE's advanced gPROMS models for biotreatment and fermentation
PSE's expert ModelCare configuration and consulting services

Collectively these bring a new level of power and high-accuracy predictive capability to biotechnology processes.

The gPROMS advantage

gPROMS is not just a process simulation package. It is a complete process modelling environment that allows the construction and execution of high-accuracy first-principles models.

Models execute within a flowsheeting and optimisation framework, and can incorporate your own laboratory or operating data where necessary.

gPROMS' many capabilities for biotechnology modelling provide it with unique advantages over other software on the market.

PSE Consulting

PSE provides expert assistance in developing, validating and executing models for any purpose under our ModelCare programme, working closely with your personnel to ensure rapid implementation and transfer of modelling know-how.

In addition, PSE Consultants can advise on and apply Model-Based Innovation techniques in order to significantly improve the quality and efficiency of data gathering while reducing experimentation time.

This leads to accelerated development, and helps in management of risk when implementing new technologies or processes.